Linerixibat
Linerixibat (GSK2330672) is a potent and nonabsorbable inhibitor of the apical sodium-dependent bile acid transporter (ASBT), with an IC50 of 42 ± 3 nM. It has demonstrated glucose-lowering efficacy in preclinical models of type 2 diabetes and exhibits favorable developability characteristics for research applications.
Product Specifications
CAS Number
1345982-69-5
Product Name Alternative
Diabetes, Cholangitis, Biliary, aqueous, ASBT, inhibit, Inhibitor, nonabsorbable, Linerixibat, lipid-lowering, PBC, GSK 2330672, GSK2330672, GSK-2330672, hASBT, Iinerixibat, solubility, Primary, type-2
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery
Purity
98.50% (May vary between batches)
Solubility
DMSO:21.5 mg/mL (39.33 mM)
Smiles
CCCC[C@]1 (CC) CS (=O) (=O) c2cc (CNC (CC (O) =O) CC (O) =O) c (OC) cc2[C@H] (N1) c1ccccc1
Molecular Formula
C28H38N2O7S
Molecular Weight
546.68
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
EH26785 96 Tests
Human NENF (Neudesin Neurotrophic Factor) ELISA Kit
Sign In for Pricing
View Details 
abx652762-01 10 µg
Human Capping Protein Muscle Z Line Beta (CAPZb) Protein
Sign In for Pricing
View Details 
abx652762-02 50 µg
Human Capping Protein Muscle Z Line Beta (CAPZb) Protein
Sign In for Pricing
View Details abx652762-03 100 µg
Human Capping Protein Muscle Z Line Beta (CAPZb) Protein
Sign In for Pricing
View Details