Linerixibat
Linerixibat (GSK2330672) is a potent and nonabsorbable inhibitor of the apical sodium-dependent bile acid transporter (ASBT), with an IC50 of 42 ± 3 nM. It has demonstrated glucose-lowering efficacy in preclinical models of type 2 diabetes and exhibits favorable developability characteristics for research applications.
Product Specifications
CAS Number
1345982-69-5
Product Name Alternative
Diabetes, Cholangitis, Biliary, aqueous, ASBT, inhibit, Inhibitor, nonabsorbable, Linerixibat, lipid-lowering, PBC, GSK 2330672, GSK2330672, GSK-2330672, hASBT, Iinerixibat, solubility, Primary, type-2
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery
Purity
98.50% (May vary between batches)
Solubility
DMSO:21.5 mg/mL (39.33 mM)
Smiles
CCCC[C@]1 (CC) CS (=O) (=O) c2cc (CNC (CC (O) =O) CC (O) =O) c (OC) cc2[C@H] (N1) c1ccccc1
Molecular Formula
C28H38N2O7S
Molecular Weight
546.68
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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