(Iso) -Flavokawain A

NSC-37445 demonstrates anti-tumor activity in models of bladder cancer, including inhibiting tumor growth and preventing recurrence in vivo. Its mechanism involves downregulating Myt1 and Wee1, leading to cyclin B1 accumulation and CDK1 activation in T24 cells. Flavokawain A exhibits anti-inflammatory effects by suppressing pro-inflammatory mediators via inhibition of NF-κB, AP-1, and MAPK signaling in macrophages.