(Iso) -Flavokawain A
NSC-37445 demonstrates anti-tumor activity in models of bladder cancer, including inhibiting tumor growth and preventing recurrence in vivo. Its mechanism involves downregulating Myt1 and Wee1, leading to cyclin B1 accumulation and CDK1 activation in T24 cells. Flavokawain A exhibits anti-inflammatory effects by suppressing pro-inflammatory mediators via inhibition of NF-κB, AP-1, and MAPK signaling in macrophages.
Product Specifications
CAS Number
3420-72-2
Product Name Alternative
Field of Research
Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Neuroscience, Protein Biochemistry, Signal Transduction
Purity
97.10% (May vary between batches)
Solubility
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble; DMSO:55 mg/mL (174.97 mM) ;10% DMSO+90% Corn Oil:2.5 mg/mL (7.95 mM)
Smiles
O=C (C=CC1=CC=C (OC) C=C1) C=2C (O) =CC (OC) =CC2OC
Molecular Formula
C18H18O5
Molecular Weight
314.332
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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