L189
L189 is a potent and selective inhibitor of human DNA ligases I, III, and IV, with IC50 values of 5, 9, and 5 μM, respectively. It is a valuable chemical tool for studying DNA repair mechanisms in vitro and has been used in research exploring the cellular response to replication stress and DNA damage.
Product Specifications
CAS Number
64232-83-3
Product Name Alternative
L 189, inhibit, L189, L-189, Inhibitor, cancer, DNA/RNA Synthesis, DNA Synthesis, DNALigase IV, DNASynthesis, DNA ligase, DNA Ligase I, DNA Ligase III, DNA Ligase IV, cytotoxicity, cell death, TMZ, RNASynthesis, RNA Synthesis
Field of Research
Cell Biology, Molecular Biology
Purity
97.37% (May vary between batches)
Solubility
H2O:Insoluble; DMSO:50 mg/mL (203.01 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.12 mM) ; Ethanol:1 mg/mL (4.06 mM)
Smiles
Nc1[nH]c (=S) [nH]c (=O) c1N=Cc1ccccc1
Molecular Formula
C11H10N4OS
Molecular Weight
246.29
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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