YHO-13177
YHO-13177 is a potent and selective BCRP inhibitor that enhances SN-38 cytotoxicity in vitro. It shows no activity against P-glycoprotein, as demonstrated in MDR1-transduced K562 cell models. This compound is a valuable research tool for investigating BCRP-mediated drug resistance in cancer.
Product Specifications
CAS Number
912287-56-0
Product Name Alternative
YHO 13177, YHO13177, YHO-13177, BCRP, ABCG2, Breast cancer resistance protein, Inhibitor, inhibit
Field of Research
Pharmacology & Drug Discovery
Purity
98.64% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.4 mM) ; DMSO:45 mg/mL (121.47 mM)
Smiles
COc1ccc (cc1OC) C (=C\c1ccc (s1) N1CCC (O) CC1) \C#N
Molecular Formula
C20H22N2O3S
Molecular Weight
370.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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