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BGG463

BGG463 (K 0859) is a potent inhibitor of c-ABL-T334I, BCR-ABL, and the resistant BCR-ABL-T315I variant with respective IC50 values of 0.25, 0.09, and 0.590 μM. This compound is a valuable research tool for studying kinase signaling and resistance mechanisms in both cellular and biochemical assays relevant to oncology research.

Product Specifications

CAS Number

890129-26-7

Product Name Alternative

K0859, K-0859, K03859, K-03859, K 0859, K 03859, inhibit, Inhibitor, Abl (T315I), Abl, BcrAbl, BGG 463, BGG463, BGG-463, c-Abl, Cyclin dependent kinase, CDK

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Purity

95.05% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.91 mM) ; DMSO:125 mg/mL (216.05 mM)

Smiles

CN1CCN (Cc2ccc (NC (=O) c3cccc4cc (Oc5cc (NC (C) =O) ncn5) ccc34) cc2C (F) (F) F) CC1

Molecular Formula

C30H29F3N6O3

Molecular Weight

578.58

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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