Vecabrutinib
Vecabrutinib (SNS-062) is a potent, noncovalent BTK and ITK inhibitor, with Kd values of 0.3 nM and 2.2 nM, respectively. Vecabrutinib shows an IC50 of 24 nM for ITK[1][2].
Product Specifications
CAS Number
1510829-06-7
Product Name Alternative
SNS-062
UNSPSC
12352005
Target
Btk; Itk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Vecabrutinib.html
Purity
99.76
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC([C@@H]1[C@@H](N(CCC[C@H]2NC3=CC(C(F)(F)F)=CC(Cl)=C3)C2=O)CN(C4=NC=NC(N)=C4F)CC1)=O
Molecular Formula
C22H24ClF4N7O2
Molecular Weight
529.92
References & Citations
[1]Minke E. Binnerts, et al. Abstract C186: SNS-062 is a potent noncovalent BTK inhibitor with comparable activity against wild type BTK and BTK with an acquired resistance mutation. Molecular Cancer Therapeutics. December 2015 Volume 14, Issue 12 Supplement 2|[2]Catherine A. Fabian, et al. Abstract 1207: SNS-062 demonstrates efficacy in chronic lymphocytic leukemia in vitro and inhibits C481S mutated Bruton tyrosine kinase. Cancer Research July 2017 Volume 77, Issue 13 Supplement
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![PFKP Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2E10]](https://cdn.genprice.uk/products/937/68dd1b6d061270361ea16daf/imageurl/ta503981bm.webp)
TA503981BM 100 µL
PFKP Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2E10]
Sign In for Pricing
View Details 
LC426339 20 µg
Activin A Receptor Type IC (ACVR1C) (NM_001111033) Human Over-expression Lysate
Sign In for Pricing
View Details 
BNC040489-500 1x 500 µL
Topoisomerase (DNA) I, Mitochondrial (TOP1MT) (TOP1MT/568), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC473063-100 1x 100 µL
CLEC9A / DNGR1 (Dendritic Cell Marker) (8F9), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details