Branaplam
Branaplam (LMI 070) is an orally bioavailable small molecule that potently and selectively modulates SMN2 splicing. It has demonstrated efficacy in increasing SMN protein levels in both cellular models and in vivo studies, supporting its research application for spinal muscular atrophy.
Product Specifications
CAS Number
1562338-42-4
Product Name Alternative
Potassium Channel, PotassiumChannel, RNA Synthesis, RNASynthesis, SMN2, SMN, SMA, splicing, spinal, survival, Inhibitor, LMI070, LMI-070, LMI 070, KcsA, motor, inhibit, muscular, orally, NVS-SM1, neuron-2, gene, hERG, DNA Synthesis, DNA/RNA Synthesis, DNASynthesis, Branaplam, atrophy
Field of Research
Cell Biology, Molecular Biology, Pharmacology & Drug Discovery
Purity
97.81% (May vary between batches)
Solubility
DMSO:3.96 mg/mL (10.06 mM)
Smiles
CC1 (C) CC (CC (C) (C) N1) Oc1ccc (nn1) -c1ccc (cc1O) -c1cn[nH]c1
Molecular Formula
C22H27N5O2
Molecular Weight
393.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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