M2I-1
M2I-1 is a first-in-class small molecule inhibitor that selectively disrupts the Mad2-Cdc20 protein-protein interaction, a key event in the spindle assembly checkpoint (SAC) . By interfering with Mad2's conformational dynamics, it serves as a valuable chemical probe for studying SAC function and aneuploidy in both cellular and biochemical assays.
Product Specifications
CAS Number
312271-03-7
Product Name Alternative
Cdc20, inhibit, Mad2, M2I 1, M2I1, M-2I-1, M2I-1, Inhibitor, interaction, PPI, protein-protein
Field of Research
Cell Biology
Purity
97.61% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.94 mM) ; DMSO:45 mg/mL (111.25 mM)
Smiles
CC (C) CN (CC (C) C) c1ccc (C=C2C (=O) NC (=S) NC2=O) cc1[N+] ([O-]) =O
Molecular Formula
C19H24N4O4S
Molecular Weight
404.48
Storage Conditions
-20°C
Notes
For research use only.
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