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WHI-P97

WHI-P97 is a potent, rationally designed JAK3 inhibitor (IC50 provided) . It suppresses IgE-mediated leukotriene synthesis in mast cells by blocking 5-lipoxygenase nuclear translocation without direct enzyme inhibition. This mechanism supports its research use in studying allergic inflammation and mast cell biology in vitro.

Product Specifications

CAS Number

211555-05-4

Product Name Alternative

Airway, inhibit, JAK, JAK3, Janus kinase, ovalbumin-sensitized, ovalbumin challenge, Inhibitor, eosinophil recruitment, WHI-P97, WHI-P-97, WHIP97, WHI P97

Field of Research

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Purity

98.91% (May vary between batches)

Solubility

DMSO:60 mg/mL (131.84 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.2 mM)

Smiles

COc1cc2ncnc (Nc3cc (Br) c (O) c (Br) c3) c2cc1OC

Molecular Formula

C16H13Br2N3O3

Molecular Weight

455.1

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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