SB297006
SB297006 is a potent and selective CCR3 antagonist (IC50 = 39 nM) that inhibits chemokine-induced calcium flux in vitro. It has demonstrated efficacy in vivo by reducing antigen-driven pulmonary recruitment of Th2 cells and eosinophils in mouse models, supporting its use in research on allergic inflammation and asthma.
Product Specifications
CAS Number
58816-69-6
Product Name Alternative
SB 297006, SB297006, SB-297006, inhibit, Inhibitor, CC chemokine receptor, CCR3, CCR
Field of Research
Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery
Purity
99.59% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.68 mM) ; H2O:< 0.1 mg/mL (insoluble) ; DMSO:150 mg/mL (438.15 mM)
Smiles
CCOC (=O) [C@H] (Cc1ccc (cc1) [N+] ([O-]) =O) NC (=O) c1ccccc1
Molecular Formula
C18H18N2O5
Molecular Weight
342.35
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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