MMAD
MMAD (Demethyldolastatin 10) is a potent tubulin-binding agent used as a cytotoxic payload in antibody-drug conjugates (ADCs) . Its mechanism of inhibiting microtubule assembly is applied in oncology research for evaluating ADC efficacy in both in vitro cytotoxicity assays and in vivo xenograft models.
Product Specifications
CAS Number
203849-91-6
Product Name Alternative
Inhibitor, Monomethyl Dolastatin 10, Monomethyl Dolastatin10, Monomethyl Dolastatin-10, Monomethylauristatin D, Microtubule Associated, MicrotubuleAssociated, Microtubule/Tubulin, MMAD, inhibit, ADCCytotoxin, ADC Cytotoxin, ADC Payload, Demethyldolastatin 10, Demethyldolastatin10, Demethyldolastatin-10
Field of Research
Signal Transduction
Purity
99.25% (May vary between batches)
Solubility
DMSO:24.5 mg/mL (31.77 mM)
Smiles
[H][C@]1 (CCCN1C (=O) C[C@@H] (OC) [C@H] ([C@@H] (C) CC) N (C) C (=O) [C@@H] (NC (=O) [C@@H] (NC) C (C) C) C (C) C) [C@H] (OC) [C@@H] (C) C (=O) N[C@@H] (Cc1ccccc1) c1nccs1
Molecular Formula
C41H66N6O6S
Molecular Weight
771.06
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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