Simeprevir
Simeprevir (TMC435) is a small molecule NS3/4A protease inhibitor with potent anti-HCV activity, demonstrating an EC50 of 8 nM in replication assays. It has been widely used in both in vitro and in vivo research to study hepatitis C virus inhibition and combination antiviral therapies.
Product Specifications
CAS Number
923604-59-5
Product Name Alternative
Field of Research
Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery, Protein Biochemistry
Purity
99.45% (May vary between batches)
Solubility
H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.33 mM) ; DMSO:55 mg/mL (73.34 mM)
Smiles
COc1ccc2c (O[C@@H]3C[C@@H]4[C@@H] (C3) C (=O) N (C) CCCC\C=C/[C@@H]3C[C@]3 (NC4=O) C (=O) NS (=O) (=O) C3CC3) cc (nc2c1C) -c1nc (cs1) C (C) C
Molecular Formula
C38H47N5O7S2
Molecular Weight
749.94
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
ASCC2 (NM_032204) Human Over-expression Lysate
RTKN2 (PLEKHK1, Rhotekin-2, Pleckstrin Homology Domain-containing Family K Member 1, DKFZp686J10120) (FITC)