Ro5-3335
Ro5-3335 is a small molecule inhibitor of the RUNX1/CBFβ transcription factor complex. It selectively targets leukemia cells harboring CBF fusions, demonstrates efficacy in reducing leukemia burden in mouse models, and also acts as a Tat antagonist to inhibit HIV-1 replication in vitro.
Product Specifications
CAS Number
30195-30-3
Product Name Alternative
Core, CBFβ-Runx1, CBFβ-Runx1 inhibitor II, CBFbeta-Runx1 inhibitor II, CBFb-Runx1 inhibitor II, CBFβ, DNASynthesis, DNA Synthesis, binding, CBF, Inhibitor, interaction, leukemia, factor, inhibit, RNA Synthesis, RNASynthesis, Ro 5-3335, RUNX1, RUNX1-CBFB, Ro5 3335, Ro53335, Ro-5-3335, Ro5-3335
Field of Research
Cell Biology, Molecular Biology
Purity
99.42% (May vary between batches)
Solubility
DMSO:60 mg/mL (231.04 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.7 mM)
Smiles
Clc1ccc2NC (=O) CN=C (c3ccc[nH]3) c2c1
Molecular Formula
C13H10ClN3O
Molecular Weight
259.69
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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