(R) -GNE-140
GNE-140 is a potent dual inhibitor of LDHA and LDHB, exhibiting IC50 values of 3 nM and 5 nM, respectively. The R-enantiomer demonstrates 18-fold greater inhibitory activity than its S-enantiomer counterpart. This inhibitor is a valuable research tool for studying cancer metabolism and has shown antitumor efficacy in preclinical in vivo models.
Product Specifications
CAS Number
2003234-63-5
Product Name Alternative
Inhibit, Inhibitor, Lactate Dehydrogenase, LDH, GNE 140, GNE140, GNE-140, (R) GNE140, (R) GNE 140
Field of Research
Metabolism Research
Purity
95.46% (May vary between batches)
Solubility
DMSO:21.43 mg/mL (42.94 mM) ; DMF:25mg/mL (50.09 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2 mM) ; H2O:< 0.1 mg/mL (insoluble)
Smiles
OC1=C (Sc2ccccc2Cl) C (=O) N[C@@] (C1) (c1ccsc1) c1ccc (cc1) N1CCOCC1
Molecular Formula
C25H23ClN2O3S2
Molecular Weight
499.04
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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