AS-2444697
AS-2444697 is a potent and selective IRAK-4 inhibitor with an IC50 of 21 nM, demonstrating activity across human and rat enzymes. Its anti-inflammatory mechanism underlies observed renoprotective effects in research models, supporting its use in studying innate immune signaling pathways in both in vitro and in vivo contexts.
Product Specifications
CAS Number
1287665-60-4
Product Name Alternative
AS2444697, AS-2444697, AS 2444697, anti-inflammatory, Inhibitor, IRAK, IRAK-4, IL-1R associated kinase, Interleukin-1 receptor associated kinase, inhibit, renoprotective
Field of Research
Immunology & Inflammation, Signal Transduction
Purity
97.17% (May vary between batches)
Solubility
DMSO:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cl.Cc1cc (ccn1) -c1nc (co1) C (=O) Nc1cn (nc1C (N) =O) C1CCOCC1
Molecular Formula
C19H21ClN6O4
Molecular Weight
432.86
Storage Conditions
-20°C
Notes
For research use only.
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