Prexasertib
Prexasertib is a potent and selective CHK1 inhibitor (Ki 0.9 nM) that induces DNA damage and apoptosis. It has demonstrated antitumor activity in both in vitro cell-based assays and in vivo xenograft models, supporting its investigation in oncology research, particularly for cancers with replication stress.
Product Specifications
CAS Number
1234015-52-1
Product Name Alternative
Checkpoint Kinase (Chk), Chk2, Chk1, CDC25A, CDK2, DNA, double-stranded, BRSK2, Apoptosis, autophosphorylation, ARK5, ATP-competitive, MELK, Inhibitor, HeLa, HT-29, H2AX, LY 2606368, LY2606368, LY-2606368, inhibit, Prexasertib, SIK, S516, S296, RSK1, replication
Field of Research
Cell Biology
Purity
97.28% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.74 mM) ; DMSO:22 mg/mL (60.21 mM)
Smiles
COc1cccc (OCCCN) c1-c1cc (Nc2cnc (cn2) C#N) n[nH]1
Molecular Formula
C18H19N7O2
Molecular Weight
365.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV644873 1.0 µg DNA
RGD1308396 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)
Sign In for Pricing
View Details 
037719-ML750 100 µL
LCP1, ID (LCP1, PLS2, Plastin-2, L-plastin, LC64P, Lymphocyte cytosolic protein 1) (MaxLight 750) discontinued
Sign In for Pricing
View Details bs-5557R-BF555 100 µL
Phospho-PTPN7 (Ser246) Polyclonal Antibody, AbBy Fluor™ 555 Conjugated
Sign In for Pricing
View Details