Prexasertib
Prexasertib is a potent and selective CHK1 inhibitor (Ki 0.9 nM) that induces DNA damage and apoptosis. It has demonstrated antitumor activity in both in vitro cell-based assays and in vivo xenograft models, supporting its investigation in oncology research, particularly for cancers with replication stress.
Product Specifications
CAS Number
1234015-52-1
Product Name Alternative
Checkpoint Kinase (Chk), Chk2, Chk1, CDC25A, CDK2, DNA, double-stranded, BRSK2, Apoptosis, autophosphorylation, ARK5, ATP-competitive, MELK, Inhibitor, HeLa, HT-29, H2AX, LY 2606368, LY2606368, LY-2606368, inhibit, Prexasertib, SIK, S516, S296, RSK1, replication
Field of Research
Cell Biology
Purity
97.28% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.74 mM) ; DMSO:22 mg/mL (60.21 mM)
Smiles
COc1cccc (OCCCN) c1-c1cc (Nc2cnc (cn2) C#N) n[nH]1
Molecular Formula
C18H19N7O2
Molecular Weight
365.39
Storage Conditions
-20°C
Notes
For research use only.
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