Prexasertib dihydrochloride
Prexasertib dihydrochloride (LY2606368) is a potent ATP-competitive inhibitor of CHK1 (Ki: 0.9 nM), also showing activity against CHK2 and RSK in biochemical assays. This small molecule is widely used in cancer research to study DNA damage response pathways and has demonstrated antitumor efficacy in both cellular and animal models.
Product Specifications
CAS Number
1234015-54-3
Product Name Alternative
S296, S516, S6 Kinase, S6Kinase, RSK1, Ribosomal S6 Kinase (RSK), SIK, Prexasertib 2HCl, Prexasertib HCl, H2AX, MELK, LY2606368 (dihydrochloride), LY2606368 2HCl, Apoptosis, ARK5, BRSK2, double-stranded, CDC25A, Chk2, Chk1, Checkpoint Kinase (Chk)
Field of Research
Cell Biology, Signal Transduction
Purity
97.50% (May vary between batches)
Solubility
DMSO:4.39 mg/mL (10.02 mM)
Smiles
Cl.Cl.COc1cccc (OCCCN) c1-c1cc (Nc2cnc (cn2) C#N) n[nH]1
Molecular Formula
C18H21Cl2N7O2
Molecular Weight
438.31
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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