CBL0137 hydrochloride
CBL0137 hydrochloride (Curaxin-137 hydrochloride) is a FACT complex inhibitor that activates p53 and suppresses NF-κB, demonstrating potent anticancer activity in vitro and in vivo. It synergizes with chemotherapeutics like cisplatin, showing efficacy in preclinical models of small cell lung cancer (SCLC) and other malignancies.
Product Specifications
CAS Number
1197397-89-9
Product Name Alternative
Curaxin 137, Curaxin 137 hydrochloride, Curaxin137, Curaxin-137, Curaxin-137 hydrochloride, CBL-0137, CBLC 137, CBL-C 137 Hydrochloride, CBLC137, CBL-C137, CBLC-137, CBLC137 hydrochloride, CBL-C137 hydrochloride, CBL-C-137 Hydrochloride, CBL 0137, CBL 0137 Hydrochloride, NF-κB, NFκB, NFkB, NF-kB, p53, FACT, MDM-2/p53
Field of Research
Cell Biology, Signal Transduction
Purity
98.59% (May vary between batches)
Solubility
DMSO:36 mg/mL (96.55 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:25 mg/mL (67.05 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.36 mM)
Smiles
Cl.CC (C) NCCn1c2ccc (cc2c2cc (ccc12) C (C) =O) C (C) =O
Molecular Formula
C21H25ClN2O2
Molecular Weight
372.88
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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