Tropifexor
Tropifexor (LJN452) is a potent, non-bile acid FXR agonist exhibiting an EC50 of 0.2 nM. It is utilized in research on metabolic diseases, including NASH and PBC, and has demonstrated efficacy in both in vitro assays and in vivo preclinical models of liver injury and fibrosis.
Product Specifications
CAS Number
1383816-29-2
Product Name Alternative
Inhibit, NR1H4, LJN 452, LJN452, LJN-452, FXR, Inhibitor, Autophagy, Tropifexor
Field of Research
Cell Biology, Metabolism Research
Purity
99.10% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.31 mM) ; DMSO:63.75 mg/mL (105.62 mM)
Smiles
OC (=O) c1cc (F) c2nc (sc2c1) N1[C@H]2CC[C@@H]1C[C@@H] (C2) OCc1c (onc1-c1ccccc1OC (F) (F) F) C1CC1
Molecular Formula
C29H25F4N3O5S
Molecular Weight
603.58
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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