Nodakenin

Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC50 of 84.7 μM[1][2].

Product Specifications

CAS Number

[495-31-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cholinesterase (ChE)

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nodakenin.html

Purity

98.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)([C@H]1CC2=CC(C=CC3=O)=C(O3)C=C2O1)O[C@@H]([C@@H]([C@@H](O)[C@@H]4O)O)O[C@@H]4CO

Molecular Formula

C20H24O9

Molecular Weight

408.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Kim DH, et al. Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice. Life Sci. 2007 May 1;80 (21) :1944-50.|[2]Xiong Y, et al. The effects of nodakenin on airway inflammation, hyper-responsiveness and remodeling in a murine model of allergic asthma. Immunopharmacol Immunotoxicol. 2014 Oct;36 (5) :341-8.