Gilteritinib
Gilteritinib is an orally active, ATP-competitive, and selective dual inhibitor of FLT3 (IC50=0.29 nM) and AXL (IC50=0.73 nM) . It demonstrates potent antitumor efficacy in both cellular assays and animal models, supporting its research application in FLT3-mutated acute myeloid leukemia (AML) .
Product Specifications
CAS Number
1254053-43-4
Product Name Alternative
ASP2215
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
>98%
Bioactivity
FLT3 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml)
Smiles
CCc1nc (C (N) =O) c (Nc2ccc (N3CCC (CC3) N3CCN (C) CC3) c (OC) c2) nc1NC1CCOCC1
Molecular Formula
C29H44N8O3
Molecular Weight
552.7
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
6-Ethyl-3-[3-methoxy-4-[4- (4-methylpiperazin-1-yl) piperidin-1-yl]anilino]-5- (oxan-4-ylamino) pyrazine-2-carboxamide
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