RO1138452
CAY10441 is a potent, selective, and orally active prostacyclin (IP) receptor antagonist with a pKi of 8.3. It effectively blocks IP receptor-mediated cAMP accumulation in vitro and demonstrates significant in vivo analgesic activity in rat models at doses of 2-20 mg/kg, making it a valuable research tool for studying pain and vascular biology.
Product Specifications
CAS Number
221529-58-4
Product Name Alternative
Prostacyclin receptor, Prostaglandin Receptor, ProstaglandinReceptor, RO1138452, RO-1138452, RO 1138452, CAY10441, CAY-10441, CAY 10441, inhibit, Inhibitor
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
95.73% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.46 mM) ; DMSO:45 mg/mL (145.44 mM)
Smiles
CC (C) Oc1ccc (Cc2ccc (NC3=NCCN3) cc2) cc1
Molecular Formula
C19H23N3O
Molecular Weight
309.41
Storage Conditions
-20°C
Notes
For research use only.
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