AZ32
AZ32 is a potent, orally bioavailable, and brain-penetrant small molecule inhibitor of ATM kinase. It demonstrates high enzymatic inhibition (IC50 <6.2 nM) and cellular activity (IC50 = 0.31 μM) . This inhibitor is a valuable tool for investigating ATM's role in DNA damage response, cancer research, and in vivo studies of central nervous system malignancies.
Product Specifications
CAS Number
2288709-96-4
Product Name Alternative
Inhibitor, inhibit, AZ 32, ATR, ATM/ATR, ATM, ATM and RAD3 related, Ataxia telangiectasia mutated, AZ32, AZ-32
Field of Research
Molecular Biology, Signal Transduction
Purity
98.68% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.09 mM) ; DMSO:55 mg/mL (167.49 mM)
Smiles
CNC (=O) c1ccc (cc1) -c1cnc2cnc (cn12) -c1ccccc1
Molecular Formula
C20H16N4O
Molecular Weight
328.37
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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