PK11000
PK11000 is a small molecule that reactivates mutant p53, restoring its tumor suppressor function. This compound demonstrates anti-tumor efficacy in cellular assays and has shown promising activity in vivo, making it a valuable tool for oncology research targeting p53-dependent pathways.
Product Specifications
CAS Number
38275-34-2
Product Name Alternative
NUGC-3, NUGC-4, MKN1, p53/MDM2, inhibit, mutant p53 cancer cells, JimT1, HUH-7, HUH-6, Inhibitor, HCC1937, HCC1143, MCF10A, MCF12A, MCF7, MDM-2/p53, Hs578T (i8), DNA Alkylator, DNA Alkylator/Crosslinker, DNAAlkylator, Crosslinker, BT474, BT549, BT20, SUM 159, T47D, SW480, SKBR3, SJSA-1, PK11000, PK-11000, PK 11000, UACC812
Field of Research
Cell Biology, Molecular Biology
Purity
99.70% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.45 mM) ; DMSO:43 mg/mL (181.72 mM)
Smiles
CS (=O) (=O) c1ncc (Cl) c (n1) C (O) =O
Molecular Formula
C6H5ClN2O4S
Molecular Weight
236.63
Storage Conditions
-20°C
Notes
For research use only.
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