Clozapine N-oxide
Clozapine N-oxide (CNO) is a brain-penetrant metabolite of clozapine and a potent agonist for DREADD receptors hM3Dq and hM4Di, widely used for chemogenetic neuronal manipulation in vivo. It also exhibits dopaminergic antagonist and muscarinic M4 receptor agonist activities, supporting its use in neuropharmacology research.
Product Specifications
CAS Number
34233-69-7
Product Name Alternative
HM3Dq, Inhibitor, G-protein, metabolite, mAChR, inhibit, Muscarinic acetylcholine receptor, muscarinic-M4, 5HTReceptor, 5HT Receptor, 5-HT, BBB, Clozapine, CLOZAPINE N OXIDE, CLOZAPINE NOXIDE, Clozapine N-oxide, CLOZAPINE N-OXIDE, DrugMetabolite, Drug Metabolite, DREADDs, Dopamine Receptor, Dopamine, DopamineReceptor
Field of Research
Neuroscience, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
DREADD agonist
Form
Powder
Solubility
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 3 mg/ml)
Smiles
CN1 (=O) CCN (C=2C=3C (NC=4C (N2) =CC (Cl) =CC4) =CC=CC3) CC1
Molecular Formula
C18H19ClN4O
Molecular Weight
342.8
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
8-Chloro-11- (4-methyl-4-oxido-1-piperazinyl) -5H-dibenzo[b, e][1,4]diazepine
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