Thalidomide-NH-CH2-COOH
This compound is a synthesized cereblon E3 ligase ligand-linker conjugate, incorporating a thalidomide derivative connected to a glycine linker. It serves as a key component in the development of PROTACs for targeted protein degradation, a strategy widely used in vitro and in vivo for probing disease-related protein functions.
Product Specifications
CAS Number
927670-97-1
Product Name Alternative
Cereblon, cereblon, CRBN, E3 ligase-recruiting Moiety, (2- (2,6-Dioxopiperidin-3-yl) -1,3-dioxoisoindolin-4-yl) glycine, 2-[[2- (2,6-dioxopiperidin-3-yl) -1,3-dioxoisoindol-4-yl]amino]acetic acid, Inhibitor, LigandforE3Ligase, Ligands for E3 Ligase, Ligand for E3 Ligase, inhibit, Thalidomide, Thalidomide NH CH2 COOH, ThalidomideNHCH2COOH, Thalidomide-NH-CH-2-COOH, Thalidomide-NH-CH2-COOH
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
96.38% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.02 mM) ; DMSO:42.5 mg/mL (128.29 mM)
Smiles
O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=CC2NCC (O) =O
Molecular Formula
C15H13N3O6
Molecular Weight
331.28
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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