Juglone
Juglone (Regianin, CAS 481-39-0) is a natural compound that potently inhibits Pin1 and other parvulin-family PPIases (Ki = 55.9 nM) . It also blocks eukaryotic RNA polymerases (IC50 2-7 μM) and has demonstrated in vivo activity in attenuating kidney fibrosis in rodent models, acting through both Pin1-dependent and independent mechanisms.
Product Specifications
CAS Number
481-39-0
Product Name Alternative
DNA Synthesis, DNASynthesis, 5-Hydroxy-1,4-naphthoquinone, antimicrobial, Bacterial, black, Inhibitor, Juglone, inhibit, RNA polymerase, RNA Synthesis, RNASynthesis, walnut, Regianin, Pigment, Yellow
Field of Research
Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology, Signal Transduction
Purity
98.73% (May vary between batches)
Solubility
DMSO:5.56 mg/mL (31.93 mM) ; Ethanol:15 mg/mL (86.13 mM)
Smiles
Oc1cccc2C (=O) C=CC (=O) c12
Molecular Formula
C10H6O3
Molecular Weight
174.15
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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