UNC926
UNC926 is a small molecule inhibitor of the methyl-lysine reader proteins L3MBTL1 (IC50: 3.9 μM) and L3MBTL3. It selectively disrupts the interaction between the L3MBTL1 3xMBT domain and the histone mark H4K20me1 without affecting 53BP1 binding, making it a useful chemical probe for epigenetic and cancer research.
Product Specifications
CAS Number
1184136-10-4
Product Name Alternative
3xMBT, methyl-lysine, L3MBTL1, L3MBTL3, H4K20me1, EpigeneticReaderDomain, Epigenetic Reader Domain, UNC 926, UNC926, UNC-926, UNC926 Hydrochloride, UNC-926 Hydrochloride
Field of Research
Epigenetics & Chromatin
Purity
96.97% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.93 mM) ; DMSO:37.4 mg/mL (110.9 mM)
Smiles
Brc1cccc (c1) C (=O) N1CCC (CC1) N1CCCC1
Molecular Formula
C16H21BrN2O
Molecular Weight
337.25
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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