Cambinol
Cambinol is a cell-permeable SIRT1 and SIRT2 inhibitor with substrate-competitive activity, also functioning as a brain-penetrant neutral sphingomyelinase (N-SMase) inhibitor. It induces apoptosis in BCL6-expressing lymphoma cells via p53 and BCL6 hyperacetylation and is used in oncology and neurology research, including in vivo studies on exosome biology and cancer models.
Product Specifications
CAS Number
14513-15-6
Product Name Alternative
Cambinol, Apoptosis, NSC112546, NSC-112546, Inhibitor, inhibit, NSC 112546, SIRT2, SIRT1, SIRT1/2 Inhibitor IV, Sirtuin, Phospholipase
Field of Research
Cell Biology, Epigenetics & Chromatin, Metabolism Research, Molecular Biology
Purity
98.02% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.55 mM) ; Ethanol:5 mg/mL (13.87 mM) ; DMSO:36 mg/mL (99.88 mM)
Smiles
Oc1ccc2ccccc2c1Cc1c ([nH]c (=S) [nH]c1=O) -c1ccccc1
Molecular Formula
C21H16N2O2S
Molecular Weight
360.43
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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