NH-3
NH-3 is a potent, orally bioavailable thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. Derived from GC-1, it reversibly blocks hormone binding and cofactor recruitment, making it a valuable tool for studying hyperthyroidism and metabolic disorders in both cellular and animal models.
Product Specifications
CAS Number
447415-26-1
Product Name Alternative
Cofactor, inhibit, Inhibitor, NH3, NH-3, NH 3, orally, GC-1, Thyroidhormonereceptor (THR), Thyroidhormonereceptor, Thyroid hormone receptor (THR), Thyroid hormone receptor, Thyroid Hormone Receptor, Thyroid hormone, thyromi-metic, THR, recruitment
Field of Research
Metabolism Research
Purity
97.09% (May vary between batches)
Solubility
DMSO:95 mg/mL (200.63 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.97 mM)
Smiles
CC (C) c1cc (Cc2c (C) cc (OCC (O) =O) cc2C) cc (C#Cc2ccc (cc2) [N+] ([O-]) =O) c1O
Molecular Formula
C28H27NO6
Molecular Weight
473.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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