R-IMPP
R-IMPP is a small molecule inhibitor that suppresses PCSK9 protein synthesis, thereby upregulating hepatic LDL receptor levels and enhancing LDL cholesterol uptake in hepatoma cell models. This mechanism, which does not affect transferrin secretion, makes it a valuable research tool for studying lipid metabolism and potential therapeutic strategies for hypercholesterolemia in both in vitro and in vivo contexts.
Product Specifications
CAS Number
2133832-83-2
Product Name Alternative
Inhibitor, inhibit, PCSK9, Ser/Thr Protease, Serine kinase, Serine endopeptidases, PF 00932239, Serine proteases, threonin kinase, Serinekinase, Threonine proteases, threoninkinase, PF-00932239, PF00932239, R IMPP, RIMPP, R-IMPP
Field of Research
Cell Biology, Metabolism Research
Purity
99.47% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.13 mM) ; DMSO:70 mg/mL (179.72 mM)
Smiles
COc1ccc (CCC (=O) N ([C@@H]2CCCNC2) c2nccc3ccccc23) cc1
Molecular Formula
C24H27N3O2
Molecular Weight
389.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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