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Selamectin

Selamectin (UK-124114) is a macrocyclic lactone anthelmintic derived from ivermectin. It acts by potentiating glutamate- and GABA-gated chloride channels in parasitic nematodes, as demonstrated by its growth inhibitory effect at 0.1 μg/ml in Haemonchus contortus larval development assays. This compound is utilized in veterinary parasitology research and in vitro studies of anthelmintic mechanisms.

Product Specifications

CAS Number

220119-17-5

Product Name Alternative

Parasite, inhibit, Multidrug resistance protein 1, MDR1, Inhibitor, ABCB1, Cl? Channels, CD243, Chloride channel, Chloride Channel, Chloridechannel, Cluster of differentiation 243, P-glycoprotein, Pgp, P-gp, P-gp (P-glycoprotein), Selamectin, UK-124114, UK124114, UK 124114

Field of Research

Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Purity

99.64% (May vary between batches)

Solubility

DMSO:90 mg/mL (116.89 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.29 mM)

Smiles

COC1CC (OC2C (C) \C=C\C=C3/COC4\C (=N\O) C (C) =CC (C (=O) OC5CC (C\C=C2/C) OC2 (CCC (C) C (O2) C2CCCCC2) C5) C34O) OC (C) C1O

Molecular Formula

C43H63NO11

Molecular Weight

769.96

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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