Butein
Butein is a multi-target small molecule that acts as a cAMP-specific PDE inhibitor, a protein tyrosine kinase inhibitor, and a SIRT1 activator. Research indicates it can sensitize HeLa cells to Cisplatin-induced cytotoxicity by modulating FoxO3a through the AKT and ERK/p38 MAPK signaling pathways, highlighting its utility in cancer research.
Product Specifications
CAS Number
487-52-5
Product Name Alternative
Cell, Apoptosis, Autophagy, Butein, AKT, 2',3,4,4'-tetrahydroxy Chalcone, EGFR, Epidermal growth factor receptor, ErbB-1, ERK, FoxO3a, HER1, HepG2, HeLa, MAPK, PDE4, p60c-src, inhibit, Inhibitor, Phosphodiesterase (PDE), phosphodiesterase, PKB, SIRT1, p38
Field of Research
Cardiovascular Research, Cell Biology, Metabolism Research, Signal Transduction
Purity
98.76% (May vary between batches)
Solubility
10% DMSO+90% Saline:2.5 mg/mL (9.18 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:51 mg/mL (187.33 mM) ; DMSO:237.5 mg/mL (872.36 mM)
Smiles
Oc1ccc (C (=O) \C=C\c2ccc (O) c (O) c2) c (O) c1
Molecular Formula
C15H12O5
Molecular Weight
272.25
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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