CYC-116
CYC116 is a potent, selective dual Aurora A/B kinase inhibitor (Ki = 8.0/9.2 nM) with weaker activity against VEGFR2 and minimal off-target effects on other key kinases. It has been utilized in preclinical research to investigate cell cycle disruption and antitumor efficacy in both cellular and animal models.
Product Specifications
CAS Number
693228-63-6
Product Name Alternative
AuroraKinase, Aurora Kinase, Aurora B, Aurora A, CYC 116, CYC116, CYC-116, CDK2/CyclinE, CDK9/CyclinT, p70 S6K, Inhibitor, inhibit, FLT3, S6Kinase, S6 Kinase, VEGFR2
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction
Purity
96.60% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:13.4 mg/mL (36.37 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cc1nc (N) sc1-c1ccnc (Nc2ccc (cc2) N2CCOCC2) n1
Molecular Formula
C18H20N6OS
Molecular Weight
368.46
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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