Droxinostat
Droxinostat is a selective histone deacetylase (HDAC) inhibitor, primarily targeting HDAC6 and HDAC8 with IC50 values of 2.47 μM and 1.46 μM, respectively. It demonstrates over 8-fold selectivity against HDAC3 and shows no activity against several other HDAC isoforms. This compound is a valuable research tool for studying epigenetic mechanisms in both cellular and animal models of cancer and neurological diseases.
Product Specifications
CAS Number
99873-43-5
Product Name Alternative
Droxinostat, cancer, Apoptosis, NS41080, NS-41080, NS 41080, inhibit, Inhibitor, hepatocellular carcinoma (HCC), HDAC9, HDAC8, HDAC3, HDAC6, HDAC, HDAC10, histone deacetylase (HDAC), Histone deacetylases
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Purity
99.76% (May vary between batches)
Solubility
DMSO:46 mg/mL (188.76 mM) ; Ethanol:46 mg/mL (188.76 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.21 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cc1cc (Cl) ccc1OCCCC (=O) NO
Molecular Formula
C11H14ClNO3
Molecular Weight
243.69
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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