Glasdegib
Glasdegib (PF-04449913) is a potent, orally active Smoothened (Smo) antagonist with an IC50 of 5 nM. This small molecule inhibitor is used in research to study Hedgehog signaling pathway dysregulation in cancers, demonstrating activity in both in vitro assays and in vivo models.
Product Specifications
CAS Number
1095173-27-5
Product Name Alternative
Smo, Smoothened, PF 04449913, PF04449913, PF-04449913, Inhibitor, inhibit, Glasdegib, Hedgehog
Field of Research
Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.34 mM) ; DMSO:48 mg/mL (128.19 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CN1CC[C@H] (C[C@@H]1c1nc2ccccc2[nH]1) NC (=O) Nc1ccc (cc1) C#N
Molecular Formula
C21H22N6O
Molecular Weight
374.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR15362751 1 Vial
Lentiviral human ADAMTS20 sgRNA gene knockout kit - Lentiviral human ADAMTS20 sgRNA gene knockout kit (25)
Sign In for Pricing
View Details MBS9329149-01 48 Well
Bovine Leptin receptor overlapping transcript-like 1, LEPROTL1 ELISA Kit
Sign In for Pricing
View Details MBS9329149-02 96 Well
Bovine Leptin receptor overlapping transcript-like 1, LEPROTL1 ELISA Kit
Sign In for Pricing
View Details MBS9329149-03 5x 96 Well
Bovine Leptin receptor overlapping transcript-like 1, LEPROTL1 ELISA Kit
Sign In for Pricing
View Details