Glasdegib
Glasdegib (PF-04449913) is a potent, orally active Smoothened (Smo) antagonist with an IC50 of 5 nM. This small molecule inhibitor is used in research to study Hedgehog signaling pathway dysregulation in cancers, demonstrating activity in both in vitro assays and in vivo models.
Product Specifications
CAS Number
1095173-27-5
Product Name Alternative
Smo, Smoothened, PF 04449913, PF04449913, PF-04449913, Inhibitor, inhibit, Glasdegib, Hedgehog
Field of Research
Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.34 mM) ; DMSO:48 mg/mL (128.19 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CN1CC[C@H] (C[C@@H]1c1nc2ccccc2[nH]1) NC (=O) Nc1ccc (cc1) C#N
Molecular Formula
C21H22N6O
Molecular Weight
374.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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