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Golvatinib

Golvatinib (E-7050) is an orally active dual inhibitor targeting c-Met and VEGFR-2 tyrosine kinases, showing potential antineoplastic activity by suppressing tumor growth and angiogenesis. It has been investigated in preclinical studies for various cancers, including hepatocellular carcinoma and glioblastoma, in both in vitro and in vivo models.

Product Specifications

CAS Number

928037-13-2

Product Name Alternative

VEGFR, VEGFR2, Vascular endothelial growth factor receptor, E7050, E-7050, E 7050, c-Met/HGFR, cMet/HGFR, c-Met, cMet, inhibit, Golvatinib, Inhibitor, HGFR

Field of Research

Cardiovascular Research, Signal Transduction

Purity

≥95% (May vary between batches)

Solubility

H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:100 mg/mL (157.81 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.31 mM)

Smiles

CN1CCN (CC1) C1CCN (CC1) C (=O) Nc1cc (Oc2ccc (NC (=O) C3 (CC3) C (=O) Nc3ccc (F) cc3) c (F) c2) ccn1

Molecular Formula

C33H37F2N7O4

Molecular Weight

633.69

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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