Indoximod
Indoximod (NLG-8189) is a methylated tryptophan analog that acts as an immune checkpoint inhibitor by targeting indoleamine 2,3-dioxygenase (IDO) . Its inhibition of IDO prevents tryptophan depletion, thereby countering T-cell anergy and immunosuppression. This small molecule is utilized in both in vitro and in vivo research to study cancer immunotherapy, autoimmune diseases, and T-cell function.
Product Specifications
CAS Number
110117-83-4
Product Name Alternative
Tryptophan, Trp mimetic, Inhibitor, IDO, NLG 8189, NLG8189, NLG-8189, mTORC1, Indoleamine 2,3-Dioxygenase, Indoleamine 2,3Dioxygenase (IDO), Indoleamine 2,3-Dioxygenase (IDO), Indoleamine2,3Dioxygenase, Indoleamine2,3Dioxygenase (IDO), Indoximod, Indoximod (NLG-8189), immunotherapeutic vaccines, inhibit, cancer, 1-Methyl-D-tryptophan
Field of Research
Immunology & Inflammation
Purity
>98%
Bioactivity
IDO modulator / tryptophan mimetic
Form
Powder
Solubility
Soluble in DMSO (greater than 25 mg/ml) .
Smiles
Cn1cc (C[C@@H] (N) C (O) =O) c2ccccc12
Molecular Formula
C12H14N2O2
Molecular Weight
218.25
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
1-Methyl-D-tryptophan
Available Sizes
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