Mitoxantrone
Mitoxantrone is a dual Topo II and PKC inhibitor (IC50=8.5 μM) with established antitumor activity. It is widely used in research models for leukemia, breast cancer, and hepatocellular carcinoma, supporting both in vitro mechanistic studies and in vivo efficacy experiments.
Product Specifications
CAS Number
65271-80-9
Product Name Alternative
Topo II, Topoisomerase, Protein kinase C, PKC, Apoptosis, antitumor, B-CLL cells, breast cancer, NSC-301739, NSC301739, lymphocytes, Mitoxantrone, mitozantrone, Orthopoxvirus, NSC 301739, inhibit, Inhibitor, HL60 cells, MCF-7, leukaemia, Endogenous Metabolite
Field of Research
Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
96.29% (May vary between batches)
Solubility
Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;5% DMSO+95% Saline:2.37 mg/mL (5.33 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:88 mg/mL (197.98 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:0.15 mg/mL (0.34 mM)
Smiles
OCCNCCNc1ccc (NCCNCCO) c2C (=O) c3c (O) ccc (O) c3C (=O) c12
Molecular Formula
C22H28N4O6
Molecular Weight
444.48
Storage Conditions
-20°C
Notes
For research use only.
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