Nelarabine
Nelarabine (GW 506U78) is a purine nucleoside analog that inhibits DNA synthesis, demonstrating potent antitumor activity with IC50 values ranging from 0.067 to 2.15 μM in cellular assays. It is widely used in research for studying T-cell acute lymphoblastic leukemia (T-ALL) and has been evaluated in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
121032-29-9
Product Name Alternative
GW 506U78, HSB-2, MOLT-4, Nelzarabine, Nelarabine, P12, NucleosideAntimetabolite, Nucleoside Antimetabolite/Analog, Nucleoside Antimetabolite, JURKAT, inhibit, Inhibitor, DND41, DNASynthesis, DNA Synthesis, DNA synthesis (ALL-SIL cells), DNA synthesis (HSB2 cells), DNA synthesis (JURKAT cells), DNA synthesis (PER-255 cells), 506U78, acute lymphoblastic leukaemia, Analog, Apoptosis, T-ALL, RNASynthesis, RNA Synthesis
Field of Research
Cell Biology, Molecular Biology, Pharmacology & Drug Discovery
Purity
97.90% (May vary between batches)
Solubility
H2O:3 mg/mL (10.09 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.36 mM) ; DMSO:5 mg/mL (16.82 mM)
Smiles
COc1nc (N) nc2n (cnc12) [C@@H]1O[C@H] (CO) [C@@H] (O) [C@@H]1O
Molecular Formula
C11H15N5O5
Molecular Weight
297.27
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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