Desmethyl Erlotinib hydrochloride
Desmethyl Erlotinib hydrochloride (OSI-420) is the pharmacologically active metabolite of the EGFR inhibitor erlotinib. It potently inhibits EGFR tyrosine kinase activity and its autophosphorylation, with IC50 values of 2 nM and 20 nM, respectively. This compound is widely used in cancer research for in vitro mechanistic studies and in vivo models of EGFR-driven tumors.
Product Specifications
CAS Number
183320-51-6
Product Name Alternative
CP 473420, CP 373420, CP-373420, CP373420, CP-473420, CP473420, DesMethyl Erlotinib (CP-473420) HCl, Desmethyl Erlotinib hydrochloride, Desmethyl Erlotinib Hydrochloride, Desmethyl Erlotinib, Drug Metabolite, DrugMetabolite, inhibit, OSI420, OSI-420, OSI 420, EGFR, Inhibitor
Field of Research
Cardiovascular Research, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
99.03% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.81 mM) ; DMSO:77 mg/mL (185.15 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cl.COCCOc1cc2ncnc (Nc3cccc (c3) C#C) c2cc1OCCO
Molecular Formula
C21H21N3O4·HCl
Molecular Weight
415.87
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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