Desmethyl Erlotinib hydrochloride
Desmethyl Erlotinib hydrochloride (OSI-420) is the pharmacologically active metabolite of the EGFR inhibitor erlotinib. It potently inhibits EGFR tyrosine kinase activity and its autophosphorylation, with IC50 values of 2 nM and 20 nM, respectively. This compound is widely used in cancer research for in vitro mechanistic studies and in vivo models of EGFR-driven tumors.
Product Specifications
CAS Number
183320-51-6
Product Name Alternative
CP 473420, CP 373420, CP-373420, CP373420, CP-473420, CP473420, DesMethyl Erlotinib (CP-473420) HCl, Desmethyl Erlotinib hydrochloride, Desmethyl Erlotinib Hydrochloride, Desmethyl Erlotinib, Drug Metabolite, DrugMetabolite, inhibit, OSI420, OSI-420, OSI 420, EGFR, Inhibitor
Field of Research
Cardiovascular Research, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
99.03% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.81 mM) ; DMSO:77 mg/mL (185.15 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cl.COCCOc1cc2ncnc (Nc3cccc (c3) C#C) c2cc1OCCO
Molecular Formula
C21H21N3O4·HCl
Molecular Weight
415.87
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
bs-3069R-BF680-TR 20 µL
Phospho-BTK (Tyr223) Polyclonal Antibody, AbBy Fluor™ 680 Conjugated
Sign In for Pricing
View Details ![Rabbit Monoclonal Carboxyl Ester Lipase/CEL Antibody (063) [DyLight 550]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
NBP2-90647R 0.1 mL
Rabbit Monoclonal Carboxyl Ester Lipase/CEL Antibody (063) [DyLight 550]
Sign In for Pricing
View Details 
135093 100 µg
ULK4 (Unc-51-like Kinase 4, Serine/threonine-protein Kinase ULK4, FAM7C1, REC01035)
Sign In for Pricing
View Details