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EMD638683

EMD638683 is a potent and selective serum- and glucocorticoid-regulated kinase (SGK) inhibitor with an IC50 of 3 μM. This small molecule is a valuable research tool for investigating SGK1's role in hypertension, renal function, and cellular ion transport in both in vitro and in vivo models.

Product Specifications

CAS Number

1181770-72-8

Product Name Alternative

Inhibitor, EMD638683, EMD-638683, EMD 638683, inhibit, SGK1, SGK, Serum and glucocorticoid-regulated kinase, Serum-glucocorticoid regulated kinase

Field of Research

Metabolism Research

Purity

95.47% (May vary between batches)

Solubility

DMSO:50 mg/mL (137.23 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.49 mM)

Smiles

CCc1c (C) c (O) ccc1C (=O) NNC (=O) C (O) c1cc (F) cc (F) c1

Molecular Formula

C18H18F2N2O4

Molecular Weight

364.34

References & Citations

Sheyda Bahiraii er al. Role of Inositol Hexakisphosphate Kinases in Vascular Smooth Muscle Cell Calcification International Journal of Molecular Sciences, (2026)

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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