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YF-2

YF-2 is a brain-penetrant small molecule activator of histone acetyltransferases (HATs) . It promotes histone H3 acetylation in the hippocampus and activates CBP, PCAF, and GCN5 with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM, respectively. This tool compound is used in neuroscience research to study epigenetic mechanisms in cognitive function and related disorders in both cellular and animal models.

Product Specifications

CAS Number

1311423-89-8

Product Name Alternative

Epigenetic Reader Domain, EpigeneticReaderDomain, GCN5, Inhibitor, HATs, HAT, Histone Acetyltransferase, HistoneAcetyltransferase, inhibit, PCAF, CBP, YF 2, YF2, YF-2

Field of Research

Epigenetics & Chromatin

Purity

99.19% (May vary between batches)

Solubility

DMSO:125 mg/mL (290.12 mM) ; H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.28 mM)

Smiles

CCOc1cccc (OCCN (C) C) c1C (=O) Nc1ccc (Cl) c (c1) C (F) (F) F

Molecular Formula

C20H22ClF3N2O3

Molecular Weight

430.85

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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