YF-2
YF-2 is a brain-penetrant small molecule activator of histone acetyltransferases (HATs) . It promotes histone H3 acetylation in the hippocampus and activates CBP, PCAF, and GCN5 with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM, respectively. This tool compound is used in neuroscience research to study epigenetic mechanisms in cognitive function and related disorders in both cellular and animal models.
Product Specifications
CAS Number
1311423-89-8
Product Name Alternative
Epigenetic Reader Domain, EpigeneticReaderDomain, GCN5, Inhibitor, HATs, HAT, Histone Acetyltransferase, HistoneAcetyltransferase, inhibit, PCAF, CBP, YF 2, YF2, YF-2
Field of Research
Epigenetics & Chromatin
Purity
99.19% (May vary between batches)
Solubility
DMSO:125 mg/mL (290.12 mM) ; H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.28 mM)
Smiles
CCOc1cccc (OCCN (C) C) c1C (=O) Nc1ccc (Cl) c (c1) C (F) (F) F
Molecular Formula
C20H22ClF3N2O3
Molecular Weight
430.85
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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