TRi-1
TRi-1 is a potent and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), exhibiting an IC50 of 12 nM. It demonstrates minimal mitochondrial off-target effects, making it a promising chemical probe for anticancer research in both cellular and animal models to investigate redox biology and therapeutic strategies.
Product Specifications
CAS Number
246020-68-8
Product Name Alternative
TXNRD1, TRi 1, TRi1, TRi-1, thioredoxin reductase 1, glutathione, FaDu, Inhibitor, inhibit, antitumor, cytosolic thioredoxin reductase 1 (TXNRD1)
Field of Research
Signal Transduction
Purity
97.14% (May vary between batches)
Solubility
DMSO:62.5 mg/mL (190.13 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.08 mM)
Smiles
COc1ccc (c (n1) S (=O) (=O) c1ccc (Cl) cc1) [N+] ([O-]) =O
Molecular Formula
C12H9ClN2O5S
Molecular Weight
328.73
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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